PROTEIN DOMAIN ORGANISATION: ADDING ORDER

Protein domain organisation: adding order

Abstract Background Domains are the building blocks of proteins.During evolution, they have been duplicated, fused and recombined, to produce proteins with novel structures and functions.Structural and genome-scale miss to mrs cookie studies have shown that pairs or groups of domains observed together in a protein are almost always found in only on

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EXERCISE TESTS IN CARDIOLOGY: PAST, PRESENT AND FUTURE (PART I)

The literary review is focused on diagnostics of coronary heart disease (CHD) with the wall-e bearbrick use of the most common functional exercise tests.The benefits and the lacks are discussed of a variety of tests for suspected CHD.The results of longitude controlled trials make now the physicians able to precisely enough estimate a risk of compl

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Exploring the intersection of epigenetics, DNA repair, and immunology from studies of ICF syndrome, an inborn error of immunity

Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome, a moen finney rare autosomal recessive disorder, manifests with hypoglobulinemia and chromosomal instability accompanied by DNA hypomethylation.Pathological variants in the DNMT3B, ZBTB24, CDCA7, or HELLS genes underlie its etiology.Activated lymphocytes from patients o

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